TURK 2025

Diabetes Mellitus (DM) is a metabolic disease that is very common worldwide. That is caused by insulin deficiency or inadequate effects of insulin on target tissues. DM has many complications such as nephropathy, retinopathy, peripheral neuropathy and cardiomyopathy due to hyperglycemia. The most common among these is neuropathy. Diabetic neuropathy is a loss of sensory function that begins in the distal lower extremities and is also characterized by pain. This situation negatively affects life satisfaction in many people and makes them dependent on drugs for a long time. Since DM is a chronic disease, herbal treatments have been used more widely in the treatment of the disease in recent years in order to have fewer side effects. Morin Hydrate is a bioflavonoid compound belonging to the Moraceae family. It is known to have antioxidant, anti-inflammatory, cardioprotective, neuroprotective, antidiabetic and antimicrobial potential. Therefore, it is aimed to investigate the protective and supportive effect of morin hydrate on nephrotoxicity due to DM. For this purpose, study groups were created: Control, Diabetes, Diabetes + Metformin, Diabetes + Metformin + MH 100 group, Diabetes + MN100 and MH100. Morin hydrated prevented lipid peroxidation, GSH depletion, and reduction of antioxidant enzyme activities, CAT, SOD and GPx. It was determined that it significantly reduced MDA level, ROS production, nNOS, and 8 OHdG expressions. It was determined that it significantly reduced the level of NF-κB, an important marker of neuroinflammation caused by hyperglycemia, and the expression of caspase 3 and Bax, markers of apoptosis.
As a result, it has been revealed that morin hydrate prevents oxidative stress, neuroinflammation and neuronal apoptosis due to hyperglycemia, has a neuroprotective effect and can also provide supportive treatment together with the reference treatment.