TURK 2025

The liver is the largest of the parenchymal organs. Each liver cell contains several thousand enzymes that catalyze the reactions of numerous metabolic pathways. There are many enzymes that are equally important for the normal state of the liver tissue and the overall metabolic processes, but have different functional purposes. Also, depending on their increased activity, liver tissue pathology is distinguished. The aim of our study was to investigate the activity of enzymes in blood serum in various liver diseases. In the course of the study, we performed biochemical assays in blood serum of patients with various liver tissue pathologies. The experimental groups were divided into 3 groups: the first group - patients with fatty liver disease, the second group - patients with choleсystitis, and the third group - patients with viral hepatitis. All patients underwent biochemical blood analysis according to standard methods. The activity of enzymes in blood serum of men and women with different liver pathologies was studied in detail. It is shown that the activity of indicator enzymes in blood serum of men with choleсystitis is higher than in blood serum of women (54.3±1.3 units/l; 58.2±5.4 units/l and 65.5±2.1). It was found that the concentration of alkaline phosphatase and lactate dehydrogenase increased in the blood serum of women with choleсystitis of the liver. The activity of indicator, secretory and excretory enzymes in the blood serum of patients with steatohepatosis was 1.5 times higher than in the control group. It is shown that hyperenzymemia develops in the body of patients with viral hepatitis. As the concentration of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase and alkaline phosphatase in blood serum of patients increases 4-4,5 times. Thus, the activity of indicator, secretory and excretory enzymes increases in liver pathology.