TAGRA 2025

Multiple sclerosis (MS) is a chronic neurodegenerative disease requiring early diagnosis for effective intervention. Current diagnostic methods, such as MRI and cerebrospinal fluid analysis, are costly, time-consuming, and lack sufficient sensitivity for early detection. MicroRNAs (miRNAs), particularly miR-145 and miR-326, have emerged as promising biomarkers due to their differential...

Background: Colostrum, an immunologically active biofluid rich in proteins, lipids, and vesicular structures, contains extracellular vesicles that exhibit remarkable stability and biocompatibility. Colostrum-derived extracellular vesicles (CDEVs) have recently attracted attention as natural nanocarriers due to their ability to withstand digestive conditions, cross biological barriers, and...

Antibiotic resistance remains one of the most pressing global health challenges, driving the urgent need for innovative strategies that can enhance the effectiveness of existing antimicrobial agents. Essential oils derived from medicinal plants, such as thyme (Thymus vulgaris), contain bioactive compounds with recognized antibacterial potential and may serve as promising adjuvants to...

Exopolysaccharides (EPS) are macromolecules with structural diversity that play important roles in various biological processes. EPSs obtained from natural sources such as plants, algae, fungi, and bacteria exhibit a broad pharmacological spectrum, including antitumor, immunomodulatory, and antioxidant effects. Microbial polysaccharides offer significant advantages over plant or animal...

The rapid rise of antibiotic-resistant bacteria and the limited development of new antimicrobial agents highlight the urgent need for alternative therapeutic strategies. One promising approach is the use of synergistic combinations of antibiotics and essential oils, which may enhance antibacterial efficacy through complementary mechanisms. Essential oils, known for their broad-spectrum...

The integration of microneedle technology into drug and vaccine delivery systems offers an innovative approach due to its advantages, such as applicability against a wide range of diseases, applicability in the field of immunology, minimally invasive structure, and high bioavailability. Microneedles, which are micron-sized needles designed to penetrate the outer layer of the skin and are...

Metal oxide nanoparticles (MONPs) have become increasingly used materials in food production and packaging processes in recent years. Titanium dioxide, zinc oxide, and silica nanoparticles, in particular, are preferred for purposes such as extending product shelf life, improving color and texture, and inhibiting microbial growth. However, the nanoscale nature of these particles complicates...

This study aimed to evaluate the effects of Genistein, an isoflavone antioxidant found in soy, on liver cancer (HepG2) and healthy (HDF) cells by assessing its influence on antioxidant activity, cell viability, and CD36-mediated lipid transport. Cells were cultured and prepared for treatment. Cell viability was measured using the MTT assay. CD36 levels were quantified with a CD36 ELISA kit....