TAGRA 2025

Arthritis is a chronic inflammatory condition that demands safer and more effective therapeutic alternatives. The present study investigated the anti-arthritic potential of UNIM-R, a polyherbal dermal oil formulated using Eucalyptus globulus oil, Ferula asafoetida resin, Matricaria chamomilla stem, Styrax benzoin resin, and Sesamum indicum seeds. The formulation was evaluated in carrageenan-induced paw oedema and Complete Freund’s Adjuvant (CFA)-induced arthritis models in rats. Acute and chronic dermal toxicity studies were conducted in accordance with OECD guidelines to assess safety. In the CFA model, post-treatment profiling of key inflammatory biomarkers included TNF-α, IL-10, IFN-γ, hyaluronic acid, and PGE2. UNIM-R significantly attenuated carrageenan-induced oedema and improved clinical and biochemical indicators of inflammation in the CFA model. Cytokine analysis revealed marked suppression of pro-inflammatory mediators (TNF-α, IFN-γ, PGE2, hyaluronic acid) alongside an increase in the anti-inflammatory cytokine IL-10. The therapeutic response was comparable to standard diclofenac gel, demonstrating robust anti-inflammatory and immunomodulatory activity. Toxicity evaluations confirmed the absence of adverse dermal reactions, supporting its safety for topical application. These findings position UNIM-R as a promising polyherbal dermal intervention for arthritis management.