TAGRA 2025

In recent years, the use of naturally derived bioactive compounds as adjunct therapeutic agents for the treatment of various diseases has received increasing attention in the medical and pharmaceutical sciences. Curcumin, as demonstrated in numerous studies, exhibits potent anti-inflammatory, antimicrobial, antiviral, and antiphrastic activities, and has proven beneficial in the management of several chronic disorders. Moreover, curcumin possesses notable anticancer properties. Curcumin (Diferuloyl Methane) is the principal active constituent of turmeric and a powerful antioxidant with significant therapeutic potential, particularly in enhancing the immune system and counteracting inflammatory and infectious pathogenic factors. Despite its broad pharmacological benefits, curcumin suffers from extremely low aqueous solubility and poor bioavailability, which substantially restrict its clinical applicability. Nanoclays hydrated silicate minerals with a layered architecture and at least one dimension in the nanoscale range have emerged as promising materials in modern industrial applications, especially in the fields of healthcare and therapeutics, due to their unique structural and physicochemical characteristics. The utilization of advanced nanotechnology and clay-based nanoparticles to improve drug delivery performance and overcome clinical limitations has become a major contemporary research focus. Reducing curcumin to the nanoscale significantly increases its solubility and enhances its therapeutic efficacy. The incorporation of plant-derived compounds into nanoclay matrices has enabled the development of a new generation of eco-friendly, biocompatible, non-chemical therapeutic agents. Modern biomedical formulations produced through micro and nanostructural engineering, combined with enhanced cell mediated therapeutic performance, represent a remarkable advancement an impressive convergence of traditional medicine with state of the art therapeutic technologies.