TAGRA 2025

Breast cancer is one of the most common cancers among Iranian women, and 7,000 women are diagnosed with this cancer annually. Currently, this technology is used in various medical fields, but one of the most important areas of nanomedicine is related to cancer treatment, because it has had very positive effects on it so far. Iron and manganese oxide nanoparticles are particles in the size range of 100 nanometers. Iron oxide nanoparticles have attracted considerable attention due to their superparamagnetic properties and potential biomedical applications due to their biocompatibility and non-toxicity. Manganese oxide nanoparticles are widely used in the decomposition of hazardous chemicals due to their catalytic properties. Laser therapy uses high-energy light to treat cancer and other diseases. Lasers can also be used to shrink or destroy tumors. Lasers are most commonly used to treat superficial cancers such as basal cell skin cancer, and early stages of some cancers such as cervical, vaginal, and non-small cell lung cancer. The aim of this study was to investigate the synergistic cytotoxic effects of laser, iron oxide, and manganese oxide on a breast cancer cell line. Materials and Methods: Nanoparticles were purchased from Merck, and their dimensions were examined using a scanning electron microscope to ensure their size. The cytotoxicity effect was evaluated by MTT assay and damage to the lysosomal membrane at time. The average diameter of nanoparticles was in the range of less than 100 nm, and the cytotoxicity effect of laser and nanoparticles individually and simultaneously with laser and nanoparticles on cancer cells showed that the simultaneous effects of nanoparticles with laser gave the best response more than the single mode in less time. This study shows that the use of nanoparticles simultaneously with laser has a more effective effect than exposure to a single intervention.