TURK 2025

Nanoemulsions have emerged as a significant carrier system in the pharmaceutical and food industries by enhancing the solubility and stability of active compounds with low bioavailability. These systems hold great potential in improving the efficacy of natural antioxidants, particularly phenolic compounds and essential oils. The literature indicates that nanoemulsions formulated with jaboticaba (Plinia peruviana) extract, thyme essential oil, curcumin, catechins, and Nigella sativa L. enhance free radical scavenging capacity and reduce oxidative stress. Antioxidant assays such as DPPH and ABTS confirm the antioxidant effects of these systems. Beyond their antioxidant properties, the effects of nanoemulsions on cancer cells constitute a crucial research area. Studies have shown that these systems suppress cancer cell proliferation, induce apoptosis, arrest the cell cycle, and inhibit metastasis. In vitro experiments conducted on prostate, colon, and breast cancer cell lines have demonstrated that nanoemulsions increase cellular toxicity and exert cytotoxic effects on cancer cells. This review examines the potential mechanisms through which nanoemulsions enhance antioxidant capacity and contribute to cancer treatment. Current research highlights nanoemulsions as a promising approach in targeted therapies. However, further validation through in vivo and clinical studies is required.