TURK 2025

Nanomaterials have emerged as a transformative tool in the field of vaccinology, particularly as advanced vaccine adjuvants. Their unique physicochemical properties, such as high surface area-to-volume ratios, tunable surface chemistry, and controlled release capabilities, make them ideal candidates for enhancing immune responses. This presentation explores the diverse applications of nanomaterials, including lipid-based nanoparticles, polymeric nanoparticles, inorganic nanoparticles, and virus-like particles, in the development of next-generation vaccine adjuvants. These materials not only improve antigen stability and delivery but also modulate immune responses by targeting specific immune cells and pathways, thereby enhancing both humoral and cellular immunity. Furthermore, the ability of nanomaterials to act as intrinsic immunostimulants, coupled with their potential for multifunctionalization, positions them as a versatile platform for addressing challenges in vaccine development, such as improving efficacy in immunocompromised populations and enabling rapid response to emerging pathogens. This talk will highlight recent advancements, mechanistic insights, and clinical applications of nanomaterial-based adjuvants, underscoring their potential to revolutionize vaccine design and delivery in the fight against infectious diseases, cancer, and other global health challenges.