TURK 2025

In physiological conditions, the interactions between blood platelets and endothelial cells play a major role in vascular reactivity and hemostasis. By contrast, increased platelet activation contributes to the pathogenesis of vascular pathology such as atherosclerosis, thrombosis, diabetes mellitus, hypertension and carcinogenesis. Nanomedicine, including nano-diagnostics and nanotherapeutics is poised to be used in the management of vascular diseases. However, the inherent risk and potential toxicity resultant from the use of nanosized (˷ 100) materials need to be carefully considered. Also, stress oxidative, cells viability and ROS production were assessed. Respiratory electron chains function, lipid peroxidation, cytochrome c, GSH, GSSG and ATP levels were investigated. Our results showed that membrane potential and integrity were seriously affect by in mitochondrial and lysosome organelles, and metabolic alteration through high lipid peroxidation, high GSSG levels, low GSH generation, and ROS over production with respiratory electron chain dysfunction can contribute to trigger a cascades of events that can be result to apoptosis and cell necrosis.